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(r)Alpha Lipoic Acid Is A Safe, Effective Pharmacologic Therapy Of Chronic Orthostatic Hypotension Associated With Low Sympathetic Tone

Chronic orthostatic hypotension (OH), affecting 10 to 30% of the elderly, is associated with falls, and increased morbidity and mortality. Current pharmacologic therapy can cause or worsen hypertension and fluid retention. (r)α lipoic acid (ALA), a powerful natural antioxidant, avoids those complications and may assist management of chronic neurogenic orthostatic hypotension (NOH). The purpose of […]

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Differential Effects of Adrenergic Antagonists (Carvedilol vs. Metoprolol) on Parasympathetic and Sympathetic Activity: A Comparison of Measures 2 of 2

BACKGROUND  Cardiovascular autonomic neuropathy (CAN) is recognized as a significant health risk, correlating with risk of heart disease, silent myocardial ischemia or sudden cardiac death. Beta-blockers are often prescribed to minimize risk.  OBJECTIVES  In this second of two articles, the effects on parasympathetic and sympathetic activity of the alpha/beta-adrenergic blocker, Carvedilol, are compared with those

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Differential Effects of Adrenergic Antagonists (Carvedilol vs. Metoprolol) on Parasympathetic and Sympathetic Activity: A Comparison of Measures 1 of 2

BACKGROUND  Cardiovascular autonomic neuropathy (CAN) is recognized as a significant health risk. Specific and sensitive measures of CAN are needed for early identification and treatment to avoid complications, preferably in the preclinical state.  OBJECTIVES  In this first of two articles, the patient cohort is described and two measures of autonomic function are reviewed: the traditional

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Ranolazine Therapy Reduces Non-ST-Segment-Elevation Myocardial Infarction and Unstable Angina in Coronary Disease Patients with Angina

Abstract High sympathetic tone and cardiac autonomic neuropathy (CAN) are associated with major adverse cardiac events (MACE). We have shown ranolazine (RAN) improves autonomic function. RAN was introduced to 51 successive anginal CD patients (RANCD). A control group of 54 successive nonanginal CD patients (NORANCD) continued baseline therapy. Mean study duration was 6.1 years, which

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Ranolazine Preserves And Improves Left Ventricular Ejection Fraction And Autonomic Measures When Added To Guideline-Driven Therapy In Chronic Heart Failure

Background Ranolazine (RAN) reduces cardiac sodium channel 1.5’s late sodium current in congestive heart failure (CHF), reducing myocardial calcium overload, potentially improving left ventricular (LV) function. RAN blocks neuronal sodium channel 1.7, potentially altering parasympathetic and sympathetic (P&S) activity. The effects of RAN on LV ejection fraction (LVEF) and P&S function in CHF were studied.

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Ranolazine Improves Autonomic Balance In Heart Failure When Added To Guideline-Driven Therapy

Background The effect of ranolazine (RAN) on cardiac autonomic balance in congestive heart failure (CHF) was studied. Methods Fifty-four CHF patients were randomized to (1) open-label RAN (RANCHF) added to usual therapy vs. (2) usual therapy (NORANCHF). Parasympathetic and sympathetic (P&S) measurements were taken at baseline and at 12 months. Results A total of 16/27

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Routine Measurements of Cardiac Parasympathetic and Sympathetic Nervous Systems Assists in Primary and Secondary Risk Stratification and Management of Cardiovascular Clinic Patients

Abstract    Objective To review our studies of the ease and importance of Parasympathetic and Sympathetic (P&S) measures in managing cardiovascular patients.  Background The autonomic nervous system is responsible for the development or progression of Hypertension (HTN), orthostasis, Coronary Disease (CAD), Congestive Heart Failure (CHF) and arrhythmias. Finally, new technology provides us with rapid, accurate

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Autonomic Mechanisms and Therapeutic Implications of Postural Diabetic Cardiovascular Abnormalities

Abstract Background Cardiovascular autonomic neuropathy (CAN) is a disorder of progressive autonomic dysfunction (AD) associated with diabetes and other chronic diseases. Orthostatic hypotension (OH) is one of the most incapacitating symptoms of CAN and AD. AD in OH can include sympathetic withdrawal (SW). To detect and diagnose SW, parasympathetic and sympathetic changes must be clearly

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Clinical Autonomic And Mitochondrial Disorders

Authors: Nicholas L. DePace; Joseph Colombo This book establishes and specifies a rigorously scientific and clinically valid basis for nonpharmaceutical approaches to many common diseases and disorders found in clinical settings. It includes lifestyle and supplement recommendations for beginning and maintaining the autonomic nervous system and mitochondrial health and wellness. The book is organized around a six-pronged

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Clinical Autonomic Dysfunction

PART 1: Introduction and History of Autonomic Nervous System Monitoring CHAPTER 1: Introduction to Parasympathetic and Sympathetic Monitoring This introductory section starts with a review of the “Old School” information commonly taught in medical school, including the anatomy of the autonomic nervous system (ANS) and its two branches, the parasympathetic and sympathetic nervous systems; the

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