Ranolazine Preserves And Improves Left Ventricular Ejection Fraction And Autonomic Measures When Added To Guideline-Driven Therapy In Chronic Heart Failure
Background Ranolazine (RAN) reduces cardiac sodium channel 1.5’s late sodium current in congestive heart failure (CHF), reducing myocardial calcium overload, potentially improving left ventricular (LV) function. RAN blocks neuronal sodium channel 1.7, potentially altering parasympathetic and sympathetic (P&S) activity. The effects of RAN on LV ejection fraction (LVEF) and P&S function in CHF were studied. […]
