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Research & Clinical Trials
— about
About Physio PS, Inc.
Doctors, researchers and clinical support staff united by one mission: to improve the
way people understand and respond to imbalances in the autonomic nervous system.
— about
About Physio PS, Inc.
Doctors, researchers and clinical support staff united by one mission: to improve the way people understand and respond to imbalances in the autonomic nervous system.
— From the CEO
Physicians Treat Symptoms. This Test Saved My Life.
Six years ago, I left a cardiology appointment with a clean bill of health. Shortly afterward, a routine Physio PS assessment revealed an unexpected finding that prompted me to take a closer look at my cardiovascular health.
That experience changed my perspective on the importance of understanding autonomic function and inspired me to create Physio PS to help healthcare providers gain objective insights that can support better-informed clinical decisions.
Steve O’Leary, CEO, Physio PS
Today, our FDA 510(k)-cleared platform is trusted by physicians and researchers globally. Supported by extensive published data, it stands alone as the only technology on the market to quantitatively measure both branches of the autonomic nervous system simultaneously.
The Physio PS software as a medical device (SaMD) gives medical professionals additional insights to support diagnosis and helps patients feel that the root cause of their condition has finally been identified.
Other companies sell a portfolio of products. Physio PS makes one: the best in the industry, designed by doctors for medical professionals and researchers.
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research
Steve O’Leary, CEO, Physio PS
— From the CEO
Physicians Treat Symptoms. This Test Saved My Life.
Steve O’Leary, CEO, Physio PS
Six years ago, I left a cardiology appointment with a clean bill of health. Shortly afterward, a routine Physio PS assessment revealed an unexpected finding that prompted me to take a closer look at my cardiovascular health.
That experience changed my perspective on the importance of understanding autonomic function and inspired me to create Physio PS to help healthcare providers gain objective insights that can support better-informed clinical decisions.
Today, our FDA 510(k)-cleared platform is trusted by physicians and researchers globally. Supported by extensive published data, it stands alone as the only technology on the market to quantitatively measure both branches of the autonomic nervous system simultaneously.
The Physio PS software as a medical device (SaMD) gives medical professionals additional insights to support diagnosis and helps patients feel that the root cause of their condition has finally been identified.
Other companies sell a portfolio of products. Physio PS makes one: the best in the industry, designed by doctors for medical professionals and researchers.
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research
— Founder and Chief Editor
Joseph Colombo, PhD, DNM, DHS
A lead author of Clinical Autonomic Dysfunction: Measurement, Indications, Therapies, and Outcomes (Springer, 2014), the reference Physio PS cites for RFa as a measure of parasympathetic activity and LFa as a measure of sympathetic activity.
Joseph Colombo, PhD, DNM, DHS
— Founder and Chief Editor
A lead author of Clinical Autonomic Dysfunction: Measurement, Indications, Therapies, and Outcomes (Springer, 2014), the reference Physio PS cites for RFa as a measure of parasympathetic activity and LFa as a measure of sympathetic activity.
— Our story
Physio PS was built around a moment
that changed everything.
Co-founder Steve O'Leary believed he was in good health until ANS monitoring revealed he had Cardiac Autonomic Neuropathy. That diagnosis, he says, saved his life. He founded Physio PS to ensure that same clarity was available to patients and physicians everywhere.
Today, the company brings together doctors, researchers, and clinical support staff united by one mission: to improve the way people understand and respond to imbalances in the autonomic nervous system. The technology is FDA 510(k) cleared, used by physicians and researchers worldwide, and backed by published research.
It's the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously, and quantitatively, giving medical professionals the complete picture other tools simply can't provide.
Doctors, researchers and clinical support staff, working from the same complete picture.
Doctors, researchers and clinical support staff, working from the same complete picture.
— Our story
Physio PS was built around a moment
that changed everything.
Co-founder Steve O'Leary believed he was in good health until ANS monitoring revealed he had Cardiac Autonomic Neuropathy. That diagnosis, he says, saved his life. He founded Physio PS to ensure that same clarity was available to patients and physicians everywhere.
Today, the company brings together doctors, researchers, and clinical support staff united by one mission: to improve the way people understand and respond to imbalances in the autonomic nervous system. The technology is FDA 510(k) cleared, used by physicians and researchers worldwide, and backed by published research.
It's the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously, and quantitatively, giving medical professionals the complete picture other tools simply can't provide.
— What the Name Means
Physio PS: Physiology, Parasympathetic and Sympathetic
The name states what the technology measures.
The autonomic nervous system has two branches that work against each other to keep the body regulated. Nearly every other tool reports them as one blended figure. Physio PS measures parasympathetic and sympathetic function independently, simultaneously and quantitatively, so medical professionals see each branch on its own.
Physio · Greek phýsis
Physiology
How the body actually functions. Each assessment reads the autonomic function of the patient in front of the medical professional, measured, not reported on a questionnaire.
Autonomic · autós + nómos
The Autonomic Nervous System
Autós, self, and nómos, law. The system that governs heart rate, blood pressure, digestion and recovery below conscious control.
P · Parasympathetic
Parasympathetic
From Greek pará, alongside. The branch that governs rest, digestion and recovery.
S · Sympathetic
Sympathetic
From Greek sympátheia, feeling together. The branch that mobilises the body under load. Physio PS resolves it as its own trace, alongside the parasympathetic.
— What the Name Means
Physio PS: Physiology, Parasympathetic and Sympathetic
The name states what the technology measures.
Physio · Greek phýsis
Physiology
How the body actually functions. Each assessment reads the autonomic function of the patient in front of the medical professional, measured, not reported on a questionnaire.
Autonomic · autós + nómos
The Autonomic Nervous System
Autós, self, and nómos, law. The system that governs heart rate, blood pressure, digestion and recovery below conscious control.
P · Parasympathetic
Parasympathetic
From Greek pará, alongside. The branch that governs rest, digestion and recovery.
S · Sympathetic
Sympathetic
From Greek sympátheia, feeling together. The branch that mobilises the body under load. Physio PS resolves it as its own trace, alongside the parasympathetic.
— Our origin
A Skeptic's Awakening
Steve O'Leary walked into his first ANS test as a skeptic. He walked out a believer, because the test told him something no other diagnostic could.
Follow-up diagnostics confirmed it. The ANS test caught what years of standard checkups missed. That moment changed everything: Steve didn't just become a patient success story, he became a man on a mission. As President and COO of Physio PS he's dedicated his life to bringing this technology to the masses of humanity.
“The healthcare world is reactive. You wait until something breaks, then you try to fix it. ANS testing flips that paradigm entirely; it's the most proactive diagnostic tool on the planet.”
Steve O'Leary CBP · President & COO, Physio PS
— The arc
— Our origin
A Skeptic's Awakening
Steve O'Leary walked into his first ANS test as a skeptic. He walked out a believer, because the test told him something no other diagnostic could.
Follow-up diagnostics confirmed it. The ANS test caught what years of standard checkups missed. That moment changed everything: Steve didn't just become a patient success story, he became a man on a mission. As President and COO of Physio PS he's dedicated his life to bringing this technology to the masses of humanity.
— The arc
— Who Uses Physio PS
Trusted by Leading Health
Systems and Universities
A sampling of Customers across the US and internationally.
Hospital Systems (9)
-NYU Langone, NY
-JFK Hospitals, NY
-Hackensack Meridian Health, NJ
-Emory Hospital, GA
-Main Line Health, PA
-Boston Children's Hospital, MA
-Mass General, MA
-UZ Brussel, Belgium
-EpiCura, Belgium
Government (3)
-Atlanta VA Medical Center, GA
-East Orange VA, NJ
-Walter Reed National Military Medical Center, MD
Universities and Medical Schools (16)
United States
-Stanford University, CA
-USC, CA
-University of Michigan, MI
-University of Alabama, AL
-University of Louisville, KY
-Temple University, PA
-Eastern Virginia Medical School, VA
-Augusta University
-Logan University
-Boston Children's Hospital, Harvard, MA
International
-Cornell University, Qatar
-University of Adelaide, Australia
-University of Manchester, UK
-University of Zagreb, Croatia
-Medical University of Sofia, Bulgaria
-Deutsches Diabetes-Zentrum, Germany
Doctors' Offices and Groups (25)
-Franklin Cardiovascular, NJ
-Wellstar Cardiovascular Medicine, GA
-Fawaz Medical and Surgical Clinic, FL
-Queens Medical NYC, NY
-Nemechek Autonomic Medicine, AZ
-Luminary Clinics, NH and SC
-Luminary Mexico
-Clinica Cardiovascular, PR
-Dr. Ramesh K. Adiraju, MD, NJ
-Dr. Antonio V. Baute, GA
-Dr. Alan Vinitsky, MD
-Dr. Christopher Droogan, PA
-Dr. Suketu Nanavati, NJ
-Dr. Michael Weintraub, NY
-Dr. Gerald Smith, PA
-Dr. Karabach, MD, NJ
-Delvis A. Celdran, MD PA, FL
-Dr. Ramon Castello, FL
-Dr. Kavtaradze, FL
-Dr. MaryBeth Ayer, FL
-Dr. Robin Hall, HI
-Dr. Swamy Venuturupalli, CA
-Dr. Jitendra Patel, OR
-Dr. Trabanco, PR
-Dr. Reillo, PR
-Dr. Anja, Australia
— Who Uses Physio PS
Trusted by Leading Health
Systems and Universities
A sampling of Customers across the US and internationally.
Hospital Systems (9)
-NYU Langone, NY
-JFK Hospitals, NY
-Hackensack Meridian Health, NJ
-Emory Hospital, GA
-Main Line Health, PA
-Boston Children's Hospital, MA
-Mass General, MA
-UZ Brussel, Belgium
-EpiCura, Belgium
Government (3)
-Atlanta VA Medical Center, GA
-East Orange VA, NJ
-Walter Reed National Military Medical Center, MD
Universities and Medical Schools (16)
United States
-Stanford University, CA
-USC, CA
-University of Michigan, MI
-University of Alabama, AL
-University of Louisville, KY
-Temple University, PA
-Eastern Virginia Medical School, VA
-Augusta University
-Logan University
-Boston Children's Hospital, Harvard, MA
International
-Cornell University, Qatar
-University of Adelaide, Australia
-University of Manchester, UK
-University of Zagreb, Croatia
-Medical University of Sofia, Bulgaria
-Deutsches Diabetes-Zentrum, Germany
Doctors' Offices and Groups (25)
-Franklin Cardiovascular, NJ
-Wellstar Cardiovascular Medicine, GA
-Fawaz Medical and Surgical Clinic, FL
-Queens Medical NYC, NY
-Nemechek Autonomic Medicine, AZ
-Luminary Clinics, NH and SC
-Luminary Mexico
-Clinica Cardiovascular, PR
-Dr. Ramesh K. Adiraju, MD, NJ
-Dr. Antonio V. Baute, GA
-Dr. Alan Vinitsky, MD
-Dr. Christopher Droogan, PA
-Dr. Suketu Nanavati, NJ
-Dr. Michael Weintraub, NY
-Dr. Gerald Smith, PA
-Dr. Karabach, MD, NJ
-Delvis A. Celdran, MD PA, FL
-Dr. Ramon Castello, FL
-Dr. Kavtaradze, FL
-Dr. MaryBeth Ayer, FL
-Dr. Robin Hall, HI
-Dr. Swamy Venuturupalli, CA
-Dr. Jitendra Patel, OR
-Dr. Trabanco, PR
-Dr. Reillo, PR
-Dr. Anja, Australia
— Why practices choose us
One product, built to be the best. Other companies sell a portfolio of products. We put everything into a single platform, designed by doctors for medical professionals and researchers.
Standards
FDA 510(k) Cleared
The technology meets U.S. medical device standards, so integrating it into a clinical protocol is a documented decision rather than an experiment.
Evidence
Backed by Published Research
The same platform has been used at multiple research institutions and has contributed to published studies and books.
Since 2019
Patented and in Practice
In business since 2019 with patented technology, serving physicians, clinics and researchers nationally and internationally.
Support
Training and Certification
Every unit ships with training and certification so your team is ready from day one, and clinical guidance continues after install.
— Why practices choose us
Standards
FDA 510(k) Cleared
The technology meets U.S. medical device standards, so integrating it into a clinical protocol is a documented decision rather than an experiment.
Evidence
Backed by Published Research
The same platform has been used at multiple research institutions and has contributed to published studies and books.
Since 2019
Patented and in Practice
In business since 2019 with patented technology, serving physicians, clinics and researchers nationally and internationally.
Support
Training and Certification
Every unit ships with training and certification so your team is ready from day one, and clinical guidance continues after install.
— Serving those who served
For Our Veterans
Veterans exposed to burn pits in Afghanistan and Iraq carry toxic burdens that mainstream medicine can't diagnose with standard tools. ANS testing gives medical professionals the diagnostic intelligence to treat, not just manage, those invisible wounds.
3.5M+
Veterans exposed to burn pits
86%
Report chronic health issues
— Conditions in focus
Sub-concussive blast load can show up in vagal tone before it shows up on imaging.
— Serving those who served
For Our Veterans
Veterans exposed to burn pits in Afghanistan and Iraq carry toxic burdens that mainstream medicine can't diagnose with standard tools. ANS testing gives medical professionals the diagnostic intelligence to treat, not just manage, those invisible wounds.
3.5M+
Veterans exposed to burn pits
86%
Report chronic health issues
Clinical focus: burn-pit and deployment toxicity · TBI · PTSD vagal-tone restoration.
Talk to an
Autonomic Expert
Fifteen minutes on the phone is usually enough to tell whether ANS monitoring belongs in your practice.
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research ✓ In Business Since 2019
— Next Step
Start Where It Makes Sense for You
FDA 510(k) cleared autonomic nervous system monitoring for clinics, home care and research. Serving physicians, clinics and researchers across the United States and worldwide.
Site
Who We Serve
Journal
Contact
603-287-1817
80 Nashua Rd, Building C, Unit G1, Londonderry, NH 03053
© 2026 Physio PS, Inc. All rights reserved. FDA 510(k) cleared · Patented · Established 2019.
Hours available on request, ask during your demo.
Copyright 2026 Physio PS, Inc. All Rights Reserved.
The material and information provided by Physio PS is for general information purposes only. You should not rely upon this material or information for basis of making healthcare, treatment, or diagnosis decisions. While Physio PS strives to provide the most correct and up-to-date information and data, Physio PS makes no representations or warranties of any kind, expressed or implied, about the completeness, accuracy, reliability, suitability, or availability with respect to the information, products, services, or related graphics contained. Any reliance placed on such material is therefore strictly at your own risk. Reporting Information is supplied under license by NCRC LLC. * ‘RFa’ is known to be a measure of Parasympathetic activity and ‘LFa’ is known to be a measure of Sympathetic activity, based on reference: Colombo J, Arora RR, DePace NL, Vinik AI, Clinical Autonomic Dysfunction: Measurement, Indications, Therapies, and Outcomes. Springer Science + Business Media, New York, NY; 2014.
— Distribution Partners
Become a Distributor
Bring ANS monitoring to the clinics in your territory, with an FDA-cleared, patented platform that medical professionals buy for results they can measure.
Five solutions to offer: the CMU, RMU and PAL systems, practice integration and research licensing
An easier purchase for your clinics: fundable billing codes, financing options and low monthly payments
Veteran-owned discounts for qualifying practices
Training and certification included with every system, so the clinics you sign are ready from day one
A clear point of difference: the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously and quantitatively
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research ✓ In Business Since 2019
— FAQ
Questions Practices Ask Before They Start
Straight answers on time, cost, clearance and fit.
How long does an assessment take?
A complete autonomic assessment is non-invasive and takes 15 minutes. It is fully automated, and the qualitative, quantitative and graphical reports are delivered without manual interpretation.
Is the technology FDA cleared?
Yes. The platform is FDA 510(k) cleared to U.S. medical device standards, patented, and backed by published research.
How is testing paid for?
The Clinical Monitoring Unit is supported by fundable billing codes. For the other systems, ask about billing code applicability during your demo. Financing options, low monthly payments and veteran-owned discounts are available to qualifying practices.
Do we need extra staff, space or a tilt table?
No. Testing integrates with your existing treatment protocols with no workflow overhaul and no tilt table required. Training and certification are included, so your team is ready from day one.
How is this different from heart rate variability tools?
It is the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously and quantitatively, rather than reporting one blended figure.
Which system fits my practice?
The CMU is a desktop system for clinics, the RMU is tablet-based and battery-powered for home care and sports medicine, and the PAL is laptop-based for medical professionals who move between facilities. A free demo is the quickest way to find the right configuration.
How do I become a distributor?
Tell us about your territory and the clinics you work with through the distributor enquiry form, or call 603-287-1817, and the team will follow up to discuss distribution.
Talk to an Autonomic Expert
Fifteen minutes on the phone is usually enough to tell whether ANS monitoring belongs in your practice.
— Next Step
Start Where It Makes Sense for You
FDA 510(k) cleared autonomic nervous system monitoring for clinics, home care and research. Serving physicians, clinics and researchers across the United States and worldwide.
Site
Who We Serve
Journal
Contact
603-287-1817
80 Nashua Rd, Building C, Unit G1, Londonderry, NH 03053
© 2026 Physio PS, Inc. All rights reserved.
FDA 510(k) cleared · Patented · Established 2019.
Hours available on request, ask during your demo.
Copyright 2026 Physio PS, Inc. All Rights Reserved.
The material and information provided by Physio PS is for general information purposes only. You should not rely upon this material or information for basis of making healthcare, treatment, or diagnosis decisions. While Physio PS strives to provide the most correct and up-to-date information and data, Physio PS makes no representations or warranties of any kind, expressed or implied, about the completeness, accuracy, reliability, suitability, or availability with respect to the information, products, services, or related graphics contained. Any reliance placed on such material is therefore strictly at your own risk. Reporting Information is supplied under license by NCRC LLC. * ‘RFa’ is known to be a measure of Parasympathetic activity and ‘LFa’ is known to be a measure of Sympathetic activity, based on reference: Colombo J, Arora RR, DePace NL, Vinik AI, Clinical Autonomic Dysfunction: Measurement, Indications, Therapies, and Outcomes. Springer Science + Business Media, New York, NY; 2014.