Cardiology & Electrophysiology
Neurology
Primary & Integrative Care
Pain & Chiropractic
Longevity & Wellness
Research & Clinical Trials
— Resources
Research Center and Clinical Resources
Articles for medical professionals, and the research license program for teams studying autonomic dysfunction.
— Journal
Reading for Medical Professionals
Short, practical pieces on what autonomic data shows and how practices use it. Every article is also linked in the footer of every page.
CLINICAL PRIMER · 6 MIN READ
What P&S Monitoring Measures, and Why Both Branches Matter
Heart rate variability alone cannot separate the two branches of the autonomic nervous system. Here is what independent, simultaneous measurement adds to a clinical picture.
DIAGNOSIS · 5 MIN READ
Cardiac Autonomic Neuropathy: The Finding Patients Rarely Feel
Cardiac Autonomic Neuropathy (CAN) can develop without noticeable symptoms. Autonomic testing can help identify underlying dysfunction, providing objective insights that may support earlier clinical assessment and intervention.
— Breakthrough research
Beyond the Brain: The ANS Connection
A 2026 study published in Brain Medicine, co-authored by Dr. Joseph Colombo, the pioneer behind Physio PS technology, enrolled more than 8,000 patients and examined autonomic dysfunction as a root cause of treatment-resistant depression.
“For too long, psychiatry has accepted the label of treatment-resistant depression as a verdict rather than a challenge.”
Dr. Michele Pato, Psychiatrist, Rutgers University
8,000+
Patients enrolled
2,000+
With depression symptoms
— Resources
Research Center and Clinical Resources
Articles for medical professionals, and the research license program for teams studying autonomic dysfunction.
— Journal
Reading for Medical Professionals
Short, practical pieces on what autonomic data shows and how practices use it. Every article is also linked in the footer of every page.
CLINICAL PRIMER · 6 MIN READ
What P&S Monitoring Measures, and Why Both Branches Matter
Heart rate variability alone cannot separate the two branches of the autonomic nervous system. Here is what independent, simultaneous measurement adds to a clinical picture.
DIAGNOSIS · 5 MIN READ
Cardiac Autonomic Neuropathy: The Finding Patients Rarely Feel
Cardiac Autonomic Neuropathy (CAN) can develop without noticeable symptoms. Autonomic testing can help identify underlying dysfunction, providing objective insights that may support earlier clinical assessment and intervention.
— Research license
Physio PS 4.0 for Approved Researchers
Physio PS 4.0 is available to approved researchers under a one-year renewable research license. The same technology that underpins the clinical monitoring units has been used at multiple research institutions and has contributed to published studies and books.
Researchers apply for access through the Research Center, licenses are reviewed and granted to approved applicants.
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research
— From the CEO
Physicians Treat Symptoms. This Test Saved My Life.
Six Years ago, I walked out of his cardiology appointment with a clean bill of health. Shortly after, a simple 15-minute Physio PS ANS assessment revealed an undetected, life-threatening “widow maker” risk hidden deep within my autonomic nervous system. This is how people drop dead from heart attacks every day, so I changed my life and now run the Company.
Steve O’Leary, CEO, Physio PS
Today, our FDA 510(k)-cleared platform is trusted by physicians and researchers globally. Supported by extensive published data, it stands alone as the only technology on the market to quantitatively measure both branches of the autonomic nervous system simultaneously.
The Physio PS software as a medical device (SaMD) gives medical professionals additional insights to support diagnosis and helps patients feel that the root cause of their condition has finally been identified.
Other companies sell a portfolio of products. Physio PS makes one: the best in the industry, designed by doctors for medical professionals and researchers.
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research
✓ In Business Since 2019
Steve O’Leary, CEO, Physio PS
— Breakthrough research
Beyond the Brain: The ANS Connection
A 2026 study published in Brain Medicine, co-authored by Dr. Joseph Colombo, the pioneer behind Physio PS technology, enrolled more than 8,000 patients and examined autonomic dysfunction as a root cause of treatment-resistant depression.
“For too long, psychiatry has accepted the label of treatment-resistant depression as a verdict rather than a challenge.”
Dr. Michele Pato, Psychiatrist, Rutgers University
— Founder and Chief Editor
Joseph Colombo, PhD, DNM, DHS
A lead author of Clinical Autonomic Dysfunction: Measurement, Indications, Therapies, and Outcomes (Springer, 2014), the reference Physio PS cites for RFa as a measure of parasympathetic activity and LFa as a measure of sympathetic activity.
— Research license
Physio PS 4.0 for Approved Researchers
Physio PS 4.0 is available to approved researchers under a one-year renewable research license. The same technology that underpins the clinical monitoring units has been used at multiple research institutions and has contributed to published studies and books.
Researchers apply for access through the Research Center, licenses are reviewed and granted to approved applicants.
✓ FDA 510(k) Cleared
✓ Patented Technology
✓ Backed by Published Research
— Next Step
Start Where It Makes Sense for You
FDA 510(k) cleared autonomic nervous system monitoring for clinics, home care and research. Serving physicians, clinics and researchers across the United States and worldwide.
Site
Who We Serve
Journal
Contact
603-287-1817
80 Nashua Rd, Building C, Unit G1, Londonderry, NH 03053
© 2026 Physio PS, Inc. All rights reserved.
FDA 510(k) cleared · Patented · Established 2019.
Hours available on request, ask during your demo.
Copyright 2026 Physio PS, Inc. All Rights Reserved.
The material and information provided by Physio PS is for general information purposes only. You should not rely upon this material or information for basis of making healthcare, treatment, or diagnosis decisions. While Physio PS strives to provide the most correct and up-to-date information and data, Physio PS makes no representations or warranties of any kind, expressed or implied, about the completeness, accuracy, reliability, suitability, or availability with respect to the information, products, services, or related graphics contained. Any reliance placed on such material is therefore strictly at your own risk. Reporting Information is supplied under license by NCRC LLC. * ‘RFa’ is known to be a measure of Parasympathetic activity and ‘LFa’ is known to be a measure of Sympathetic activity, based on reference: Colombo J, Arora RR, DePace NL, Vinik AI, Clinical Autonomic Dysfunction: Measurement, Indications, Therapies, and Outcomes. Springer Science + Business Media, New York, NY; 2014.
Joseph Colombo, PhD, DNM, DHS
— Founder and Chief Editor
A lead author of Clinical Autonomic Dysfunction: Measurement, Indications, Therapies, and Outcomes (Springer, 2014), the reference Physio PS cites for RFa as a measure of parasympathetic activity and LFa as a measure of sympathetic activity.
— Our story
Physio PS was built around a moment
that changed everything.
Co-founder Steve O'Leary thought he was in good health, until a routine 15-minute ANS monitoring session revealed he had Cardiac Autonomic Neuropathy.
That diagnosis, he says, saved his life. He founded Physio PS to ensure that same clarity was available to patients and physicians everywhere.
Today, the company brings together doctors, researchers, and clinical support staff united by one mission: to improve the way people understand and respond to imbalances in the autonomic nervous system. The technology is FDA 510(k) cleared, used by physicians and researchers worldwide, and backed by published research.
It's the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously, and quantitatively, giving medical professionals the complete picture other tools simply can't provide.
Doctors, researchers and clinical support staff, working from the same complete picture.
Doctors, researchers and clinical support staff, working from the same complete picture.
— Our story
Physio PS was built around a moment
that changed everything.
Co-founder Steve O'Leary thought he was in good health, until a routine 15-minute ANS monitoring session revealed he had Cardiac Autonomic Neuropathy.
That diagnosis, he says, saved his life. He founded Physio PS to ensure that same clarity was available to patients and physicians everywhere.
Today, the company brings together doctors, researchers, and clinical support staff united by one mission: to improve the way people understand and respond to imbalances in the autonomic nervous system. The technology is FDA 510(k) cleared, used by physicians and researchers worldwide, and backed by published research.
It's the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously, and quantitatively, giving medical professionals the complete picture other tools simply can't provide.
— What the Name Means
Physio PS: Physiology, Parasympathetic and Sympathetic
The name states what the technology measures.
The autonomic nervous system has two branches that work against each other to keep the body regulated. Nearly every other tool reports them as one blended figure. Physio PS measures parasympathetic and sympathetic function independently, simultaneously and quantitatively, so medical professionals see each branch on its own.
Physio · Greek phýsis
Physiology
How the body actually functions. Each assessment reads the autonomic function of the patient in front of the medical professional, measured, not reported on a questionnaire.
Autonomic · autós + nómos
The Autonomic Nervous System
Autós, self, and nómos, law. The system that governs heart rate, blood pressure, digestion and recovery below conscious control.
P · Parasympathetic
Parasympathetic
From Greek pará, alongside. The branch that governs rest, digestion and recovery.
S · Sympathetic
Sympathetic
From Greek sympátheia, feeling together. The branch that mobilises the body under load. Physio PS resolves it as its own trace, alongside the parasympathetic.
— What the Name Means
Physio PS: Physiology, Parasympathetic and Sympathetic
The name states what the technology measures.
Physio · Greek phýsis
Physiology
How the body actually functions. Each assessment reads the autonomic function of the patient in front of the medical professional, measured, not reported on a questionnaire.
Autonomic · autós + nómos
The Autonomic Nervous System
Autós, self, and nómos, law. The system that governs heart rate, blood pressure, digestion and recovery below conscious control.
P · Parasympathetic
Parasympathetic
From Greek pará, alongside. The branch that governs rest, digestion and recovery.
S · Sympathetic
Sympathetic
From Greek sympátheia, feeling together. The branch that mobilises the body under load. Physio PS resolves it as its own trace, alongside the parasympathetic.
— Our origin
A Skeptic's Awakening
Steve O'Leary walked into his first ANS test as a skeptic. He walked out a believer, because the test told him something no other diagnostic could.
Follow-up diagnostics confirmed it. The ANS test caught what years of standard checkups missed. That moment changed everything: Steve didn't just become a patient success story, he became a man on a mission. As President and COO of Physio PS he's dedicated his life to bringing this technology to the masses of humanity.
“The healthcare world is reactive. You wait until something breaks, then you try to fix it. ANS testing flips that paradigm entirely; it's the most proactive diagnostic tool on the planet.”
Steve O'Leary CBP · President & COO, Physio PS
— The arc
— Our origin
A Skeptic's Awakening
Steve O'Leary walked into his first ANS test as a skeptic. He walked out a believer, because the test told him something no other diagnostic could.
Follow-up diagnostics confirmed it. The ANS test caught what years of standard checkups missed. That moment changed everything: Steve didn't just become a patient success story, he became a man on a mission. As President and COO of Physio PS he's dedicated his life to bringing this technology to the masses of humanity.
— The arc
— Who Uses Physio PS
Trusted by Leading Health
Systems and Universities
Sampling of Customers across the US and internationally.
Hospital Systems (9)
-NYU Langone, NY
-JFK Hospitals, NY
-Hackensack Meridian Health, NJ
-Emory Hospital, GA
-Main Line Health, PA
-Boston Children's Hospital, MA
-Mass General, MA
-UZ Brussel, Belgium
-EpiCura, Belgium
Government (3)
-Atlanta VA Medical Center, GA
-East Orange VA, NJ
-Walter Reed National Military Medical Center, MD
Universities and Medical Schools (16)
United States
-Stanford University, CA
-USC, CA
-University of Michigan, MI
-University of Alabama, AL
-University of Louisville, KY
-Temple University, PA
-Eastern Virginia Medical School, VA
-Augusta University
-Logan University
-Boston Children's Hospital, Harvard, MA
International
-Cornell University, Qatar
-University of Adelaide, Australia
-University of Manchester, UK
-University of Zagreb, Croatia
-Medical University of Sofia, Bulgaria
-Deutsches Diabetes-Zentrum, Germany
Doctors' Offices and Groups (25)
-Franklin Cardiovascular, NJ
-Wellstar Cardiovascular Medicine, GA
-Fawaz Medical and Surgical Clinic, FL
-Queens Medical NYC, NY
-Nemechek Autonomic Medicine, AZ
-Luminary Clinics, NH and SC
-Luminary Mexico
-Clinica Cardiovascular, PR
-Dr. Ramesh K. Adiraju, MD, NJ
-Dr. Antonio V. Baute, GA
-Dr. Alan Vinitsky, MD
-Dr. Christopher Droogan, PA
-Dr. Suketu Nanavati, NJ
-Dr. Michael Weintraub, NY
-Dr. Gerald Smith, PA
-Dr. Karabach, MD, NJ
-Delvis A. Celdran, MD PA, FL
-Dr. Ramon Castello, FL
-Dr. Kavtaradze, FL
-Dr. MaryBeth Ayer, FL
-Dr. Robin Hall, HI
-Dr. Swamy Venuturupalli, CA
-Dr. Jitendra Patel, OR
-Dr. Trabanco, PR
-Dr. Reillo, PR
-Dr. Anja, Australia
— Who Uses Physio PS
Trusted by Leading Health
Systems and Universities
Sampling of Customers across the US and internationally.
Hospital Systems (9)
-NYU Langone, NY
-JFK Hospitals, NY
-Hackensack Meridian Health, NJ
-Emory Hospital, GA
-Main Line Health, PA
-Boston Children's Hospital, MA
-Mass General, MA
-UZ Brussel, Belgium
-EpiCura, Belgium
Government (3)
-Atlanta VA Medical Center, GA
-East Orange VA, NJ
-Walter Reed National Military Medical Center, MD
Universities and Medical Schools (16)
United States
-Stanford University, CA
-USC, CA
-University of Michigan, MI
-University of Alabama, AL
-University of Louisville, KY
-Temple University, PA
-Eastern Virginia Medical School, VA
-Augusta University
-Logan University
-Boston Children's Hospital, Harvard, MA
International
-Cornell University, Qatar
-University of Adelaide, Australia
-University of Manchester, UK
-University of Zagreb, Croatia
-Medical University of Sofia, Bulgaria
-Deutsches Diabetes-Zentrum, Germany
Doctors' Offices and Groups (25)
-Franklin Cardiovascular, NJ
-Wellstar Cardiovascular Medicine, GA
-Fawaz Medical and Surgical Clinic, FL
-Queens Medical NYC, NY
-Nemechek Autonomic Medicine, AZ
-Luminary Clinics, NH and SC
-Luminary Mexico
-Clinica Cardiovascular, PR
-Dr. Ramesh K. Adiraju, MD, NJ
-Dr. Antonio V. Baute, GA
-Dr. Alan Vinitsky, MD
-Dr. Christopher Droogan, PA
-Dr. Suketu Nanavati, NJ
-Dr. Michael Weintraub, NY
-Dr. Gerald Smith, PA
-Dr. Karabach, MD, NJ
-Delvis A. Celdran, MD PA, FL
-Dr. Ramon Castello, FL
-Dr. Kavtaradze, FL
-Dr. MaryBeth Ayer, FL
-Dr. Robin Hall, HI
-Dr. Swamy Venuturupalli, CA
-Dr. Jitendra Patel, OR
-Dr. Trabanco, PR
-Dr. Reillo, PR
-Dr. Anja, Australia
— Why practices choose us
One product, built to be the best. Other companies sell a portfolio of products. We put everything into a single platform, designed by doctors for medical professionals and researchers.
Standards
FDA 510(k) Cleared
The technology meets U.S. medical device standards, so integrating it into a clinical protocol is a documented decision rather than an experiment.
Evidence
Backed by Published Research
The same platform has been used at multiple research institutions and has contributed to published studies and books.
Since 2019
Patented and in Practice
In business since 2019 with patented technology, serving physicians, clinics and researchers nationally and internationally.
Support
Training and Certification
Every unit ships with training and certification so your team is ready from day one, and clinical guidance continues after install.
— Why practices choose us
Standards
FDA 510(k) Cleared
The technology meets U.S. medical device standards, so integrating it into a clinical protocol is a documented decision rather than an experiment.
Evidence
Backed by Published Research
The same platform has been used at multiple research institutions and has contributed to published studies and books.
Since 2019
Patented and in Practice
In business since 2019 with patented technology, serving physicians, clinics and researchers nationally and internationally.
Support
Training and Certification
Every unit ships with training and certification so your team is ready from day one, and clinical guidance continues after install.
— Serving those who served
For Our Veterans
Veterans exposed to burn pits in Afghanistan and Iraq carry toxic burdens that mainstream medicine can't diagnose with standard tools. ANS testing gives medical professionals the diagnostic intelligence to treat, not just manage, those invisible wounds.
3.5M+
Veterans exposed to burn pits
86%
Report chronic health issues
— Conditions in focus
Sub-concussive blast load can show up in vagal tone before it shows up on imaging.
— Serving those who served
For Our Veterans
Veterans exposed to burn pits in Afghanistan and Iraq carry toxic burdens that mainstream medicine can't diagnose with standard tools. ANS testing gives medical professionals the diagnostic intelligence to treat, not just manage, those invisible wounds.
3.5M+
Veterans exposed to burn pits
86%
Report chronic health issues
Clinical focus: burn-pit and deployment toxicity · TBI · PTSD vagal-tone restoration.
Talk to an
Autonomic Expert
Fifteen minutes on the phone is usually enough to tell whether ANS monitoring belongs in your practice.
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research ✓ In Business Since 2019
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research
— Next Step
Start Where It Makes Sense for You
FDA 510(k) cleared autonomic nervous system monitoring for clinics, home care and research. Serving physicians, clinics and researchers across the United States and worldwide.
Site
Who We Serve
Journal
Contact
603-287-1817
80 Nashua Rd, Building C, Unit G1, Londonderry, NH 03053
© 2026 Physio PS, Inc. All rights reserved. FDA 510(k) cleared · Patented · Established 2019.
Hours available on request, ask during your demo.
Copyright 2026 Physio PS, Inc. All Rights Reserved.
The material and information provided by Physio PS is for general information purposes only. You should not rely upon this material or information for basis of making healthcare, treatment, or diagnosis decisions. While Physio PS strives to provide the most correct and up-to-date information and data, Physio PS makes no representations or warranties of any kind, expressed or implied, about the completeness, accuracy, reliability, suitability, or availability with respect to the information, products, services, or related graphics contained. Any reliance placed on such material is therefore strictly at your own risk. Reporting Information is supplied under license by NCRC LLC. * ‘RFa’ is known to be a measure of Parasympathetic activity and ‘LFa’ is known to be a measure of Sympathetic activity, based on reference: Colombo J, Arora RR, DePace NL, Vinik AI, Clinical Autonomic Dysfunction: Measurement, Indications, Therapies, and Outcomes. Springer Science + Business Media, New York, NY; 2014.
ANS Monitoring That Gives Medical
Professionals Real Answers
Real-Time
Autonomic Nervous
System Testing
in 15 Minutes
Measure what's important by providing more
information for a better diagnosis.
Physio PS delivers FDA-cleared autonomic nervous
system testing (used by physicians and researchers
worldwide) in a non-invasive, 15-minute session.
See the technology live in a 60-minute
virtual session.
• FDA 510(k) Cleared
• Peer-Reviewed Science
• HIPAA-Aligned
• Proactive Healthcare Starts Here
What Happens During the Test
- Seated Baseline
- Deep Breathing
- Return to Baseline
- Valsalva
- Standing
ANS Monitoring That Gives Medical
Professionals Real Answers
Real-Time Autonomic Nervous System Testing in 15 Minutes
What Happens During the Test
- Seated Baseline
- Deep Breathing
- Return to Baseline
- Valsalva
- Standing
See the technology live in a 60-minute virtual session.
— For Your Practice
See More High-Value Patients
Many autonomic patients spend a decade seeing four or five doctors who focus only on symptoms. Be the practice that identifies the underlying cause, and the provider patients will travel to see.
Differentiation
The only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously and quantitatively.
Reputation
Become the regional destination for a diagnosis nobody else in your area offers.
Referrals
Colleagues send you the cases they cannot resolve, and those patients come back for everything else.
Revenue
A new, supportable revenue line backed by fundable billing codes, without adding staff.
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research ✓ In Business Since 2019
— For Your Practice
See More High-Value Patients
Many autonomic patients spend a decade seeing four or five doctors who focus only on symptoms. Be the practice that identifies the underlying cause, and the provider patients will travel to see.
Differentiation
The only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously and quantitatively.
Reputation
Become the regional destination for a diagnosis nobody else in your area offers.
Referrals
Colleagues send you the cases they cannot resolve, and those patients come back for everything else.
Revenue
A new, supportable revenue line backed by fundable billing codes, without adding staff.
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research ✓ In Business Since 2019
— Physician and Patient Voices
What Physicians and Patients
Say About Working With Us
Medical professionals using the technology in practice, and a patient who found an answer through it.
— Physician and Patient Voices
What Physicians and Patients
Say About Working With Us
Medical professionals using the technology in practice, and a patient who found an answer through it.
— Your Specialty
What Autonomic Testing
Adds to Your Practice
ANS Monitoring for Sports Performance
Quantify the autonomic contribution to dysrhythmia, syncope and heart failure, with
both branches measured independently in a 15-minute session.
Roughly 80% of atrial dysrhythmias involve the P&S systems; monitoring specifies which branch, rather than treating all of them as cardiogenic
Congestive heart failure shows a rising sympathetic baseline up to four days before the 3% weight-gain indicator
Vasovagal, neurogenic and cardiogenic syncope separate on the stand response, where tilt-table struggles to differentiate
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research ✓ In Business Since 2019
— Your Specialty
What Autonomic Testing
Adds to Your Practice
ANS Monitoring for Sports Performance
Quantify the autonomic contribution to dysrhythmia, syncope and heart failure, with both branches measured independently in a 15-minute session.
Roughly 80% of atrial dysrhythmias involve the P&S systems; monitoring specifies which branch, rather than treating all of them as cardiogenic
Congestive heart failure shows a rising sympathetic baseline up to four days before the 3% weight-gain indicator
Vasovagal, neurogenic and cardiogenic syncope separate on the stand response, where tilt-table struggles to differentiate
— The Unsolved Cases
Every Medical Professional Has the Patients They Could Not Close the Loop On
The POTS case that bounced between cardiology and psychiatry. The Long-COVID or PTSD patient whose labs come back normal while the symptoms stay real. The patient who has already seen everyone and tells you so.
Those visits cost time, and they leave without an answer or a follow-up. Autonomic dysfunction affects an estimated 90 million people, and most of it is never measured. When you can measure it, the unsolved case becomes a solved one, and a referral source.
POTS, differentiated from syncope by the direction of the sympathetic response to standing
Long-COVID, with the autonomic component quantified when standard testing reads normal
PTSD, where the quality-of-life symptoms are autonomic and therefore measurable
Forty-three conditions in total, each with the parasympathetic or sympathetic pattern behind it
— The Unsolved Cases
Every Medical Professional Has the Patients They Could Not Close the Loop On
The POTS case that bounced between cardiology and psychiatry. The Long-COVID or PTSD patient whose labs come back normal while the symptoms stay real. The patient who has already seen everyone and tells you so.
Those visits cost time, and they leave without an answer or a follow-up. Autonomic dysfunction affects an estimated 90 million people, and most of it is never measured. When you can measure it, the unsolved case becomes a solved one, and a referral source.
POTS, differentiated from syncope by the direction of the sympathetic response to standing
Long-COVID, with the autonomic component quantified when standard testing reads normal
PTSD, where the quality-of-life symptoms are autonomic and therefore measurable
Forty-three conditions in total, each with the parasympathetic or sympathetic pattern behind it
15
Minutes for a complete, non-invasive autonomic assessment.
510(k)
FDA cleared to U.S. medical device standards.
2019
In business since 2019, with patented technology.
2/2
Both ANS branches measured independently and simultaneously.
— The technology
The Only P&S Test On the Market
Most autonomic monitoring only measures the sympathetic nervous system or heart rate variability. Physio PS monitors both Parasympathetic and Sympathetic branches independently, simultaneously, and quantitatively, using algorithmic measurement of LFa and RFa.
Independent P&S monitoring. Simultaneously and independently quantify Parasympathetic (RFa) and Sympathetic (LFa) activity: dual-branch precision no other technology on the market achieves.
15-minute test. A simple, non-invasive monitoring session that reveals what standard tests miss. No needles, no radiation, no risk.
FDA 510(k) cleared. A regulatory-cleared medical device backed by peer-reviewed clinical research and validated diagnostic algorithms.
Portable and deployable. Battery-powered, compact design for clinics, in-home care, sports medicine, field deployment and mobile diagnostics.
Revenue generator. Supported by fundable billing codes, with multiple purchase options.
Dual-branch measurement validated by Colombo et
al. Clinical Autonomic Dysfunction: Measurement,
Indications, Therapies, Springer.
— The technology
The Only P&S Test On the Market
Most autonomic monitoring only measures the sympathetic nervous system or heart rate variability. Physio PS monitors both Parasympathetic and Sympathetic branches independently, simultaneously, and quantitatively, using algorithmic measurement of LFa and RFa.
Independent P&S monitoring. Simultaneously and independently quantify Parasympathetic (RFa) and Sympathetic (LFa) activity: dual-branch precision no other technology on the market achieves.
15-minute test. A simple, non-invasive monitoring session that reveals what standard tests miss. No needles, no radiation, no risk.
FDA 510(k) cleared. A regulatory-cleared medical device backed by peer-reviewed clinical research and validated diagnostic algorithms.
Portable and deployable. Battery-powered, compact design for clinics, in-home care, sports medicine, field deployment and mobile diagnostics.
Revenue generator. Supported by fundable billing codes, with multiple purchase options.
Dual-branch measurement validated by Colombo et
al. Clinical Autonomic Dysfunction: Measurement,
Indications, Therapies, Springer.
— Clinical impact
50+ Conditions. One Platform.
ANS testing provides physicians with actionable data across an unprecedented spectrum of diseases and disorders, many of which go undetected by standard diagnostic methods.
— Clinical impact
50+ Conditions.
One Platform.
ANS testing provides physicians with actionable data across an unprecedented spectrum of diseases and disorders, many of which go undetected by standard diagnostic methods.
ANS testing provides measurements, not a diagnosis. Medical professionals interpret the results alongside the patient's history, examination, and other findings.
— Solutions
5 Ways to Bring Autonomic Testing Into the Work You Already Do
From a desktop unit in a clinic room to a research license for a university lab, every configuration runs the same proprietary software and the same automated reporting.
— Solutions
5 Ways to Bring Autonomic Testing Into the Work You Already Do
From a desktop unit in a clinic room to a research license for a university lab, every configuration runs the same proprietary software and the same automated reporting.
Clinical Monitoring Unit (CMU)
The Clinical Monitoring Unit is a desktop-based ANS monitoring system designed for any clinic environment. FDA 510(k) cleared and supported by fundable billing codes, the CMU gives your practice a deeper look at autonomic function, while opening a new, supportable revenue stream.
ANS Monitoring Integration
ANS monitoring integration from Physio PS helps medical practices add autonomic function testing to existing treatment protocols, with automated workflows, patient-facing reports, and clinical guidance included. No complex setup, no steep learning curve, and potential for cash-based add-on services.
Remote Monitoring Unit (RMU)
The Remote Monitoring Unit is a portable, tablet-based ANS monitoring system built for in-home care providers and sports medicine practitioners. Battery-powered and compact, it brings the same complete autonomic function testing to any setting, without being tethered to a clinic.
Portable Autonomic Lab (PAL)
The Portable Autonomic Lab is a laptop-based ANS monitoring solution built for the medical professional who moves between facilities or works in the field. Multiple power options and a compact form factor mean you get complete autonomic function testing wherever the work takes you.
Research Software Program (Physio PS 4.0)
Physio PS 4.0 is a research-grade ANS software program available to approved researchers on a one-year renewable license. Built on the same platform trusted by physicians worldwide, it gives research teams the autonomic monitoring tools needed for rigorous, publishable work.
Clinical Monitoring Unit (CMU)
The Clinical Monitoring Unit is a desktop-based ANS monitoring system designed for any clinic environment. FDA 510(k) cleared and supported by fundable billing codes, the CMU gives your practice a deeper look at autonomic function, while opening a new, supportable revenue stream.
ANS Monitoring Integration
ANS monitoring integration from Physio PS helps medical practices add autonomic function testing to existing treatment protocols, with automated workflows, patient-facing reports, and clinical guidance included. No complex setup, no steep learning curve, and potential for cash-based add-on services
Remote Monitoring Unit (RMU)
The Remote Monitoring Unit is a portable, tablet-based ANS monitoring system built for in-home care providers and sports medicine practitioners. Battery-powered and compact, it brings the same complete autonomic function testing to any setting, without being tethered to a clinic.
Portable Autonomic Lab (PAL)
The Portable Autonomic Lab is a laptop-based ANS monitoring solution built for the medical professional who moves between facilities or works in the field. Multiple power options and a compact form factor mean you get complete autonomic function testing wherever the work takes you.
Research Software Program (Physio PS 4.0)
Physio PS 4.0 is a research-grade ANS software program available to approved researchers on a one-year renewable license. Built on the same platform trusted by physicians worldwide, it gives research teams the autonomic monitoring tools needed for rigorous, publishable work.
— Return on Investment
Low Barrier to
Entry, Fast Return
The assessment is non-invasive, takes fifteen minutes, and is supported by fundable billing codes. It runs inside your existing protocols rather than replacing them, so the cost of adopting it is measured in training hours rather than in a rebuild of your practice.
Veteran-owned discounts for qualifying practices
Financing options with low monthly payments, so the equipment does not sit against your capital budget
Fundable billing codes that add a documented revenue line without adding staff burden
Cash-based add-on services: biofeedback and recovery coaching, preventive screenings, performance packages
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research
✓ In Business Since 2019
— Return on Investment
Low Barrier to Entry, Fast Return
The assessment is non-invasive, takes fifteen minutes, and is supported by fundable billing codes. It runs inside your existing protocols rather than replacing them, so the cost of adopting it is measured in training hours rather than in a rebuild of your practice.
Veteran-owned discounts for qualifying practices
Financing options with low monthly payments, so the equipment does not sit against your capital budget
Fundable billing codes that add a documented revenue line without adding staff burden
Cash-based add-on services: biofeedback and recovery coaching, preventive screenings, performance packages
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research ✓ In Business Since 2019
— About Physio PS, Inc.
A Diagnosis That Saved a Life, Turned into a Company
Co-founder Steve O'Leary thought he was in good health, until a routine 15-minute ANS monitoring session revealed he had Cardiac Autonomic Neuropathy. That diagnosis, he says, saved his life.
Today the company brings together doctors, researchers, and clinical support staff united by one mission: to improve the way people understand and respond to imbalances in the autonomic nervous system.
The only solution on the market that measures both parasympathetic and
sympathetic branches independently, simultaneously, and quantitatively.
— About Physio PS, Inc.
A Diagnosis That Saved a Life, Turned into a Company
Co-founder Steve O'Leary thought he was in good health, until a routine 15-minute ANS monitoring session revealed he had Cardiac Autonomic Neuropathy. That diagnosis, he says, saved his life.
Today the company brings together doctors, researchers, and clinical support staff united by one mission: to improve the way people understand and respond to imbalances in the autonomic nervous system.
— Where it is used
Serving Those Who Served, and the Clinics Around Them
Veterans exposed to burn pits in Afghanistan and Iraq carry toxic burdens that mainstream medicine can't diagnose with standard tools. ANS testing gives medical professionals the diagnostic intelligence to treat, not just manage, those invisible wounds.
3.5M+
Veterans exposed to burn pits
86%
Report chronic health issues
Clinical focus: burn-pit and deployment toxicity · TBI · PTSD vagal-tone restoration.
— Target markets
— Collaboration
Our Trusted Research Partners
— Collaboration
Our Trusted Research Partners
— Distribution Partners
Become a Distributor
Bring ANS monitoring to the clinics in your territory, with an FDA-cleared, patented platform that medical professionals buy for results they can measure.
Five solutions to offer: the CMU, RMU and PAL systems, practice integration and research licensing
An easier purchase for your clinics: fundable billing codes, financing options and low monthly payments
Veteran-owned discounts for qualifying practices
Training and certification included with every system, so the clinics you sign are ready from day one
A clear point of difference: the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously and quantitatively
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research ✓ In Business Since 2019
— Distribution Partners
Become a Distributor
Bring ANS monitoring to the clinics in your territory, with an FDA-cleared, patented platform that medical professionals buy for results they can measure.
Five solutions to offer: the CMU, RMU and PAL systems, practice integration and research licensing
An easier purchase for your clinics: fundable billing codes, financing options and low monthly payments
Veteran-owned discounts for qualifying practices
Training and certification included with every system, so the clinics you sign are ready from day one
A clear point of difference: the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously and quantitatively
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research ✓ In Business Since 2019
— FAQ
Questions Practices Ask Before They Start
Straight answers on time, cost, clearance and fit.
✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research ✓ In Business Since 2019
How long does an assessment take?
A complete autonomic assessment is non-invasive and takes 15 minutes. It is fully automated, and the qualitative, quantitative and graphical reports are delivered without manual interpretation.
Is the technology FDA cleared?
Yes. The platform is FDA 510(k) cleared to U.S. medical device standards, patented, and backed by published research.
How is testing paid for?
The Clinical Monitoring Unit is supported by fundable billing codes. For the other systems, ask about billing code applicability during your demo. Financing options, low monthly payments and veteran-owned discounts are available to qualifying practices.
Do we need extra staff, space or a tilt table?
No. Testing integrates with your existing treatment protocols with no workflow overhaul and no tilt table required. Training and certification are included, so your team is ready from day one.
How is this different from heart rate variability tools?
It is the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously and quantitatively, rather than reporting one blended figure.
Which system fits my practice?
The CMU is a desktop system for clinics, the RMU is tablet-based and battery-powered for home care and sports medicine, and the PAL is laptop-based for medical professionals who move between facilities. A free demo is the quickest way to find the right configuration.
How do I become a distributor?
Tell us about your territory and the clinics you work with through the distributor enquiry form, or call 603-287-1817, and the team will follow up to discuss distribution.
— FAQ
Questions Practices Ask Before They Start
Straight answers on time, cost, clearance and fit.
How long does an assessment take?
A complete autonomic assessment is non-invasive and takes 15 minutes. It is fully automated, and the qualitative, quantitative and graphical reports are delivered without manual interpretation.
Is the technology FDA cleared?
Yes. The platform is FDA 510(k) cleared to U.S. medical device standards, patented, and backed by published research.
How is testing paid for?
The Clinical Monitoring Unit is supported by fundable billing codes. For the other systems, ask about billing code applicability during your demo. Financing options, low monthly payments and veteran-owned discounts are available to qualifying practices.
Do we need extra staff, space or a tilt table?
No. Testing integrates with your existing treatment protocols with no workflow overhaul and no tilt table required. Training and certification are included, so your team is ready from day one.
How is this different from heart rate variability tools?
It is the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously and quantitatively, rather than reporting one blended figure.
Which system fits my practice?
The CMU is a desktop system for clinics, the RMU is tablet-based and battery-powered for home care and sports medicine, and the PAL is laptop-based for medical professionals who move between facilities. A free demo is the quickest way to find the right configuration.
How do I become a distributor?
Tell us about your territory and the clinics you work with through the distributor enquiry form, or call 603-287-1817, and the team will follow up to discuss distribution.
Talk to an Autonomic Expert
Fifteen minutes on the phone is usually enough to tell whether ANS monitoring belongs in your practice.