— Diagnosis

Cardiac Autonomic Neuropathy: The Finding Patients Rarely Feel

CAN can develop without noticeable symptoms. Autonomic testing can help identify potential autonomic dysfunction, providing objective insights that may support clinical assessment and timely intervention.

— Diagnosis

Cardiac Autonomic Neuropathy: The Finding Patients Rarely Feel

CAN can develop without noticeable symptoms. Autonomic testing can help identify potential autonomic dysfunction, providing objective insights that may support clinical assessment and timely intervention.

By the Physio PS clinical team · Published 24 april 2026 · 5 min read

Cardiac Autonomic Neuropathy is damage to the autonomic nerves that regulate the heart and blood vessels. Its early stages are quiet. A patient can feel well, perform normally, and still have a measurable loss of autonomic regulation.

Physio PS exists because of exactly that gap. Co-founder Steve O'Leary believed he was in good health until routine ANS monitoring revealed he had Cardiac Autonomic Neuropathy. That diagnosis, he says, saved his life.

By the Physio PS clinical team · Published 24 april 2026 · 5 min read

Cardiac Autonomic Neuropathy is damage to the autonomic nerves that regulate the heart and blood vessels. Its early stages are quiet. A patient can feel well, perform normally, and still have a measurable loss of autonomic regulation.

Physio PS exists because of exactly that gap. Co-founder Steve O'Leary believed he was in good health until routine ANS monitoring revealed he had Cardiac Autonomic Neuropathy. That diagnosis, he says, saved his life.

Why It Goes Unnoticed

The symptoms that eventually appear (exercise intolerance, dizziness on standing, blunted heart-rate response) are easy to attribute to age, deconditioning or medication. Nothing about them points a medical professional at the autonomic nervous system unless something in the workup does.

Clinical note: autonomic assessment is a measurement, not a diagnosis. It gives the medical professional quantitative branch-level data to weigh alongside history, examination and the rest of the workup.

What Measurement Adds

An assessment that reports parasympathetic and sympathetic function separately shows whether a reduced response is a parasympathetic loss, a sympathetic excess, or both. That distinction shapes what a medical professional does next, and it establishes a baseline that later sessions can be compared against.

Why It Goes Unnoticed

The symptoms that eventually appear (exercise intolerance, dizziness on standing, blunted heart-rate response) are easy to attribute to age, deconditioning or medication. Nothing about them points a medical professional at the autonomic nervous system unless something in the workup does.

Clinical note: autonomic assessment is a measurement, not a diagnosis. It gives the medical professional quantitative branch-level data to weigh alongside history, examination and the rest of the workup.

What Measurement Adds

An assessment that reports parasympathetic and sympathetic function separately shows whether a reduced response is a parasympathetic loss, a sympathetic excess, or both. That distinction shapes what a medical professional does next, and it establishes a baseline that later sessions can be compared against.

Fitting It Into a Visit

The assessment is non-invasive, with automated reporting generated upon completion. Practices can incorporate testing into an annual visit, diabetes review, or cardiology follow-up, allowing providers to establish a baseline while the patient is already in the office.

Fitting It Into a Visit

The assessment is non-invasive, with automated reporting generated upon completion. Practices can incorporate testing into an annual visit, diabetes review, or cardiology follow-up, allowing providers to establish a baseline while the patient is already in the office.

The Short Version

CAN is easier to act on early, and early is usually before the patient notices anything. A short, repeatable measurement is what makes early possible.

Want to see this in a live session? Book a free demo and we will walk through real reports with an autonomic expert.

✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research

The Short Version

CAN is easier to act on early, and early is usually before the patient notices anything. A short, repeatable measurement is what makes early possible.

Want to see this in a live session? Book a free demo and we will walk through real reports with an autonomic expert.

✓ FDA 510(k) Cleared ✓ Patented Technology ✓ Backed by Published Research

— Keep reading

clinical primer · 6 MIN READ

What P&S Monitoring Measures, and Why Both Branches Matter

— Keep reading

CLINICAL PRIMER · 6 MIN READ

What P&S Monitoring Measures, and Why Both Branches Matter

FDA 510(k) cleared autonomic nervous system monitoring for clinics, home care and research. Serving physicians, clinics and researchers across the United States and worldwide.

Journal

Contact

603-287-1817

80 Nashua Rd, Building C, Unit G1, Londonderry, NH 03053

© 2026 Physio PS, Inc. All rights reserved. FDA 510(k) cleared · Patented · Established 2019.

Hours available on request, ask during your demo.

Copyright 2026 Physio PS, Inc. All Rights Reserved.

The material and information provided by Physio PS is for general information purposes only. You should not rely upon this material or information for basis of making healthcare, treatment, or diagnosis decisions. While Physio PS strives to provide the most correct and up-to-date information and data, Physio PS makes no representations or warranties of any kind, expressed or implied, about the completeness, accuracy, reliability, suitability, or availability with respect to the information, products, services, or related graphics contained. Any reliance placed on such material is therefore strictly at your own risk. Reporting Information is supplied under license by NCRC LLC. * ‘RFa’ is known to be a measure of Parasympathetic activity and ‘LFa’ is known to be a measure of Sympathetic activity, based on reference: Colombo J, Arora RR, DePace NL, Vinik AI, Clinical Autonomic Dysfunction: Measurement, Indications, Therapies, and Outcomes. Springer Science + Business Media, New York, NY; 2014.

— FAQ

Questions Practices Ask Before They Start

Straight answers on time, cost, clearance and fit.

How long does an assessment take?

A complete autonomic assessment is non-invasive and takes 15 minutes. It is fully automated, and the qualitative, quantitative and graphical reports are delivered without manual interpretation.

Is the technology FDA cleared?

Yes. The platform is FDA 510(k) cleared to U.S. medical device standards, patented, and backed by published research.

How is testing paid for?

The Clinical Monitoring Unit is supported by fundable billing codes. For the other systems, ask about billing code applicability during your demo. Financing options, low monthly payments and veteran-owned discounts are available to qualifying practices.

Do we need extra staff, space or a tilt table?

No. Testing integrates with your existing treatment protocols with no workflow overhaul and no tilt table required. Training and certification are included, so your team is ready from day one.

How is this different from heart rate variability tools?

It is the only solution on the market that measures both parasympathetic and sympathetic branches independently, simultaneously and quantitatively, rather than reporting one blended figure.

Which system fits my practice?

The CMU is a desktop system for clinics, the RMU is tablet-based and battery-powered for home care and sports medicine, and the PAL is laptop-based for medical professionals who move between facilities. A free demo is the quickest way to find the right configuration.

How do I become a distributor?

Tell us about your territory and the clinics you work with through the distributor enquiry form, or call 603-287-1817, and the team will follow up to discuss distribution.

FDA 510(k) cleared autonomic nervous system monitoring for clinics, home care and research. Serving physicians, clinics and researchers across the United States and worldwide.

Journal

Contact

603-287-1817

80 Nashua Rd, Building C, Unit G1, Londonderry, NH 03053

© 2026 Physio PS, Inc. All rights reserved.

FDA 510(k) cleared · Patented · Established 2019.

Hours available on request, ask during your demo.

Copyright 2026 Physio PS, Inc. All Rights Reserved.

The material and information provided by Physio PS is for general information purposes only. You should not rely upon this material or information for basis of making healthcare, treatment, or diagnosis decisions. While Physio PS strives to provide the most correct and up-to-date information and data, Physio PS makes no representations or warranties of any kind, expressed or implied, about the completeness, accuracy, reliability, suitability, or availability with respect to the information, products, services, or related graphics contained. Any reliance placed on such material is therefore strictly at your own risk. Reporting Information is supplied under license by NCRC LLC. * ‘RFa’ is known to be a measure of Parasympathetic activity and ‘LFa’ is known to be a measure of Sympathetic activity, based on reference: Colombo J, Arora RR, DePace NL, Vinik AI, Clinical Autonomic Dysfunction: Measurement, Indications, Therapies, and Outcomes. Springer Science + Business Media, New York, NY; 2014.